SHORT INFORMATION ON PC3, IFRD1/PC4, PC3B PC3 Cloning of the PC3 gene (PNAS 1991) PC3 is a marker of newborn neurons throughout the neural tube (Mech.Dev 1994) PC3 inhibits cell proliferation (Cell Growth Diff. 1996) PC3 acts as G1 checkpoint by inhibiting cyclin D1 (Mol.Cell.Biol. 2000) Control of proliferation and differentiation of neuronal precursors by PC3 (Neuroreport 2002, J.Neurosci. 2004) Review (J.Cell.Physiol. 2001) Inhibition of medulloblastoma tumorigenesis by the antiproliferative and prodifferentiative gene PC3 (FASEB J., 2007) IFRD1/PC4 Cloning as immediate early NGF-inducible gene in rat (PNAS 1989) PC4 is required for muscle differentiation, as shown by antisense strategy and antibody microinjection (Cell Growth Diff. 1995) Cloning of human PC4, and establishment of a family of genes named IFRD (interferon-related developmental regulators) in compliance with the HGMW nomenclature (Genomics 1998) Molecular mechanism underlying the requirement of PC4 in muscle differentiation (Mol.Cell.Biol. 2005) Reviews implying PC4 mechanisms: MyoD-HDACs.pdf , MEF2-HDACs.pdf PC3B Cloning in human and mouse, as gene related to the cell cycle inhibitory domain GR of PC3 (Genomics 2000)

Tirone, BTG2, Tis21, PC3, Neurogenesis, Neural precursors, PC3B, Math1, Interferon-related developmental regulator, IFRD1, PC4, Tis7, Myogenesis, Muscle regeneration, Muscle differentiation, MyoD, MEF2, Histone deacetylases, Cerebellum